Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.

@article{Mueller2008IdentificationAB,
  title={Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.},
  author={Niklaus H. Mueller and Nagarajan Pattabiraman and Camilo Ansarah-Sobrinho and Prasanth Viswanathan and Theodore C Pierson and Rugmani Padmanabhan},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 9},
  pages={3385-93}
}
West Nile virus and dengue virus are mosquito-borne flaviviruses that cause a large number of human infections each year. No vaccines or chemotherapeutics are currently available. These viruses encode a serine protease that is essential for polyprotein processing, a required step in the viral replication cycle. In this study, a high-throughput screening assay for the West Nile virus protease was employed to screen approximately 32,000 small-molecule compounds for identification of inhibitors… CONTINUE READING

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

Nature Structural &Molecular Biology • 2006
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