Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus.

Abstract

The major envelope glycoprotein of the causative agent of Acquired Immune Deficiency Syndrome (AIDS) lymphadenopathy-associated virus (LAV) has been identified and characterized. The glycoprotein has an apparent molecular weight of 110,000-120,000 under denaturing conditions in polyacrylamide gel electrophoresis. Upon deglycosylation by a specific endoglycosydase, its size is reduced to 80,000. Cellular precursors of this glycoprotein have been detected with apparent molecular weight of 150,000 and 135,000. Nearly all AIDS and pre-AIDS patients have detectable antibodies against this viral glycoprotein.

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@article{Montagnier1985IdentificationAA, title={Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus.}, author={Luc Montagnier and François Clavel and Bernard Krust and S. Chamaret and Françoise Rey and Françoise Barr{\'e}-Sinoussi and Jean Claude Chermann}, journal={Virology}, year={1985}, volume={144 1}, pages={283-9} }