Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates

@inproceedings{Zhang2009IdentificationAA,
  title={Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates},
  author={Zhengdong D. Zhang and Adam Frankish and Toby Hunt and Jennifer L. Harrow and Mark B Gerstein},
  booktitle={Genome Biology},
  year={2009}
}
Unitary pseudogenes are a class of unprocessed pseudogenes without functioning counterparts in the genome. They constitute only a small fraction of annotated pseudogenes in the human genome. However, as they represent distinct functional losses over time, they shed light on the unique features of humans in primate evolution. We have developed a pipeline to detect human unitary pseudogenes through analyzing the global inventory of orthologs between the human genome and its mammalian relatives… CONTINUE READING

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