Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.

@article{Harigaya2010IdentificationAA,
  title={Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.},
  author={Yuriko Harigaya and Brittnee N. Jones and Denise Muhlrad and John D Gross and Roy Parker},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 6},
  pages={1446-56}
}
Cap hydrolysis is a critical control point in the life of eukaryotic mRNAs and is catalyzed by the evolutionarily conserved Dcp1-Dcp2 complex. In Saccharomyces cerevisiae, decapping is modulated by several factors, including the Lsm family protein Edc3, which directly binds to Dcp2. We show that Edc3 binding to Dcp2 is mediated by a short peptide sequence located C terminal to the catalytic domain of Dcp2. This sequence is required for Edc3 to stimulate decapping activity of Dcp2 in vitro, for… CONTINUE READING

From This Paper

Topics from this paper.
19 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…