Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins Published, JLR Papers in Press, November 16, 2004. DOI 10.1194/jlr.M400311-JLR200

@article{Milne2005IdentificationAA,
  title={Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins Published, JLR Papers in Press, November 16, 2004. DOI 10.1194/jlr.M400311-JLR200},
  author={Ginger L. Milne and Jennifer R Seal and Christine M. Havrilla and Maikel Wijtmans and Ned A. Porter},
  journal={Journal of Lipid Research},
  year={2005},
  volume={46},
  pages={307 - 319}
}
Phospholipids reside in the surface layer of LDLs and constitute ∼20–25% of the particle by weight. We report a study of the primary products generated from the most abundant molecular species of phosphatidylcholines present in LDL during in vitro free radical oxidations. The 13-hydroperoxides of 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (PLPC) and 1-stearoyl-2-linoleoyl-sn-glycero-phosphocholine (SLPC) and the 15-hydroperoxides of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine… Expand
Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha).
TLDR
The results clearly indicate that the extent of oxidation increases in the order of LDL-1< LDL-2<<LDL-3 and that the oxidative status of LDL in plasma can be quantitatively evaluated by using AE-HPLC and biomarkers, tHODE, t7-OHCh, and t8-iso-PGF(2alpha). Expand
Effect of Sterol Structure on the Physical Properties of 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine Membranes Determined Using (2)H Nuclear Magnetic Resonance.
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The notion that the VLDL-LpL axis may facilitate the delivery of plasma oxylipins to the periphery is supported, as these molecules are plausible indicators of systemic oxidative stress, and could report this status to the peripheral tissues. Expand
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These studies have, for the first time, definitively characterized novel, highly reactive A/J-ring IsoP compounds that form in abundance from the oxidation of EPA in vivo. Expand
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A review of the work published on the use of mass spectrometry in identifying oxidized phospholipids from the different classes using the soft ionization methods (electrospray and matrix-assisted laser desorption ionization). Expand
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Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo
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It is suggested that the activation of Nrf2 by oxidized phospholipids provides a mechanism by which their deleterious effects are limited in the vasculature. Expand
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