Identification and analysis of mutations in the katG gene in multidrug-resistant Mycobacterium tuberculosis clinical isolates.

@article{Jagielski2013IdentificationAA,
  title={Identification and analysis of mutations in the katG gene in multidrug-resistant Mycobacterium tuberculosis clinical isolates.},
  author={Tomasz Jagielski and Magdalena Joanna Grzeszczuk and Michał F. Kamiński and Katarzyna Roeske and Agnieszka Napi{\'o}rkowska and Radosław Stachowiak and Ewa Augustynowicz-Kope{\'c} and Zofia Zwolska and Jacek Bielecki},
  journal={Pneumonologia i alergologia polska},
  year={2013},
  volume={81 4},
  pages={298-307}
}
INTRODUCTION A major role in the development of resistance of Mycobacterium tuberculosis to isoniazid (INH) is attributed to mutations in the katG gene coding for the catalase/peroxidase, an enzyme required for obtaining a pharmacologically active form of the drug. Analysis of mutations in the katG gene in M. tuberculosis strains may contribute to the development of reliable and rapid tests for detection of INH resistance. The aim of the study was to identify and characterize mutations in the… CONTINUE READING

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