Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.

@article{Oezguen2008IdentificationAA,
  title={Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.},
  author={Numan Oezguen and S. Nagendra Kumar and Aditya Hindupur and Werner Braun and Bilikallahalli K. Muralidhara and James R. Halpert},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 31},
  pages={
          21808-16
        }
}
Using a multiple alignment of 175 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified with the program PCPMer. Functional importance of the CSM in CYP2B enzymes was assessed from available data on site-directed mutants and genetic variants. These analyses suggested an important role of the CSM 8, which corresponds to(187)RFDYKD(192) in CYP2B4. Further analysis showed that residues 187, 188, 190, and 192 have a very high rank order of conservation… CONTINUE READING
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