Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31.

@article{France2015IdentificationAA,
  title={Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31.},
  author={David J France and Gillian Stepek and Douglas R. Houston and Lewis G. Williams and G Mccormack and Malcolm D. Walkinshaw and Antony P. Page},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 24},
  pages={5752-5}
}
Infection by parasitic nematodes is widespread in the developing world causing extensive morbidity and mortality. Furthermore, infection of animals is a global problem, with a substantial impact on food production. Here we identify small molecule inhibitors of a nematode-specific metalloprotease, DPY-31, using both known metalloprotease inhibitors and… CONTINUE READING