Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis.

@article{Huang2005IdentificationAA,
  title={Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-\{alpha\}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis.},
  author={Hairong Huang and Michael S. Scherman and Wim D'Haeze and Danny Vereecke and Marcelle Holsters and Dean C Crick and Michael R. McNeil},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={
          24539-43
        }
}
Decaprenylphosphoryl-d-arabinose, the lipid donor of mycobacterial d-arabinofuranosyl residues, is synthesized from phosphoribose diphosphate rather than from a sugar nucleotide. The first committed step in the process is the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate to decaprenyl phosphate to form decaprenylphosphoryl-5-phosphoribose via a 5-phospho-alpha-d-ribose-1-diphosphate:decaprenyl-phosphate 5-phospho-ribosyltransferase. A candidate for the gene encoding this… CONTINUE READING

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