Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

@article{Zender2006IdentificationAV,
  title={Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach},
  author={Lars Zender and Mona S. Spector and Wen Xue and Peer Flemming and Carlos Cordon-Cardo and John Silke and Sheung-tat Fan and John Moon-Ching Luk and Michael Wigler and Gregory J Hannon and David Mu and Robert Lucito and Scott Powers and Scott W Lowe},
  journal={Cell},
  year={2006},
  volume={125},
  pages={1253-1267}
}
The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. Herein we describe a mouse model of liver cancer initiated from progenitor cells harboring defined cancer-predisposing lesions. Genome-wide analyses of tumors in this mouse model and in human hepatocellular carcinomas revealed a recurrent amplification at mouse chromosome 9qA1, the syntenic region of human chromosome 11q22. Gene-expression… CONTINUE READING
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