Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain.

@article{Foley2004IdentificationAH,
  title={Identification and H2O2 sensitivity of the major constitutive MAPK phosphatase from rat brain.},
  author={Timothy D. Foley and John J. Armstrong and Brian R. Kupchak},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={315 3},
  pages={568-74}
}
The present study examined in subcellular fractions from rat brain the nature and sensitivity to hydrogen peroxide of constitutively expressed mitogen-activated protein kinase (MAPK) phosphatase activity. MAPK phosphatase activity was defined as the activity directed towards a dual-phosphorylated (pT/pY) peptide corresponding to the activation domain of the extracellular-regulated kinase (ERK) subtype of the MAPKs. The use of phosphatase inhibitors and biochemical analyses demonstrate that the… CONTINUE READING
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