Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors

@article{VanSickle2005IdentificationAF,
  title={Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors},
  author={Marja D Van Sickle and Marnie Duncan and Philip J. Kingsley and Abdeslam Mouihate and Paolo Urbani and Ken Mackie and Nephi Stella and Alexandros Makriyannis and Daniele Piomelli and Joseph Davison and Lawrence J. Marnett and Vincenzo Di Marzo and Quentin J. Pittman and Kamala D Patel and Keith A. Sharkey},
  journal={Science},
  year={2005},
  volume={310},
  pages={329 - 332}
}
The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors. CB2 receptors represent an alternative site of action of endocannabinoids that opens the… Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study
TLDR
This work has performed immunohistochemical analysis of tissue sections of white matter areas of the human cerebellum and detected the presence of CB2 receptors in perivascular microglial cells, which match with the well‐known immunomodulatory role ofCB2 receptors and open new perspectives on the possible role that these receptors may play in pathophysiological events. Expand
Role of endogenous cannabinoids in synaptic signaling.
TLDR
The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release. Expand
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
TLDR
It is considered premature to rename cannabinoid receptors after an endogenous agonist as is recommended by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, because pharmacological evidence for the existence of additional types of cannabinoid receptor is emerging and other kinds of supporting evidence are still lacking. Expand
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors.
TLDR
These studies clearly indicate that 2-AG and other related compounds may function as agonists on VR1 receptors, as well as CB1 and CB2 receptors, and implicated these factors in various HBEC functions. Expand
Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret.
TLDR
CB1r mediates the anti-emetic action of cannabinoids in the dorsal vagal complex and is found in the myenteric plexus of the stomach and duodenum and a novel neuroregulatory system involved in the control of emesis. Expand
Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor.
TLDR
The data in this study suggest that the discrepancies in affinities between rat and human may represent species differences, and the rat CB( 2) receptor genomic clone will be a useful tool for studying the function and regulation of CB(2) in rats. Expand
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
TLDR
The results suggest that cannabinoid CB(2) receptor-specific ligands may be clinically useful in the modulation of macrophage immune function while exhibiting no central nervous system activity. Expand
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
TLDR
The endogenous cannabinoid system provides on-demand protection against acute excitotoxicity in central nervous system neurons and could not be triggered in mutant mice. Expand
Brain monoglyceride lipase participating in endocannabinoid inactivation
TLDR
The results suggest that hydrolysis by means of MGL is a primary mechanism for 2-AG inactivation in intact neurons, and not on the accumulation of anandamide, another endocannabinoid lipid. Expand
The cannabinoid system and immune modulation
TLDR
It appears the immunocannabinoid system is involved in regulating the brain‐immune axis and might be exploited in future therapies for chronic diseases and immune deficiency. Expand
...
1
2
3
...