Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes

  title={Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes},
  author={Florian C Bischoff and Astrid Werner and David John and Jes Niels Boeckel and Maria-Theodora Melissari and Phillip Grote and Simone F Glaser and Shemsi Demolli and Shizuka Uchida and Katharina M. Michalik and Benjamin Meder and Hugo A. Katus and Jan Haas and Wei Chen and Soni Savai Pullamsetti and Werner Seeger and Andreas M. Zeiher and Stefanie Dimmeler and Christoph M. Zehendner},
  journal={Circulation Research},
Rationale: Pericytes are essential for vessel maturation and endothelial barrier function. Long noncoding RNAs regulate many cellular functions, but their role in pericyte biology remains unexplored. Objective: Here, we investigate the effect of hypoxia-induced endoplasmic reticulum stress regulating long noncoding RNAs (HypERlnc, also known as ENSG00000262454) on pericyte function in vitro and its regulation in human heart failure and idiopathic pulmonary arterial hypertension. Methods and… 

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