Identification and Functional Characterization of Trans-acting Factors Involved in Vegetal mRNA Localization in Xenopus Oocytes

@inproceedings{Arthur2008IdentificationAF,
  title={Identification and Functional Characterization of Trans-acting Factors Involved in Vegetal mRNA Localization in Xenopus Oocytes},
  author={Patrick Kobina Arthur},
  year={2008}
}
Directional transport of specific mRNAs is a mechanism for the generation of asymmetry which is of primary biological importance. In Xenopus oocytes, mRNA localization to the vegetal cortex is important for germ layer formation and germ cell development. Using a biochemical purification approach for enriching localizing RNPs based on their large size, Xenopus Elr-type proteins which are in 4 isoforms, homologs of the Hu/ELAV proteins, were identified as novel components of the vegetal… CONTINUE READING

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