Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens

Abstract

Purpose Many proteins in the lens undergo extensive posttranslational modifications (PTMs) with age, leading to alterations in their function. The extent to which lens gap junction proteins, Cx46 and Cx50, accumulate PTMs with aging is not known. In this study, we identified truncations in Cx46 and Cx50 in the human lens using mass spectrometry. We also… (More)
DOI: 10.1167/iovs.16-19698

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@inproceedings{Slavi2016IdentificationAF, title={Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens}, author={Nefeli Slavi and Zhen Wang and Lucas Harvey and Kevin L. Schey and M. Sanjeev Srinivas}, booktitle={Investigative ophthalmology & visual science}, year={2016} }