Identification and Characterization of an IκB Kinase

@article{Rgnier1997IdentificationAC,
  title={Identification and Characterization of an I$\kappa$B Kinase},
  author={Catherine H. R{\'e}gnier and Ho Yeong Song and Xiong-Zhuo Gao and David Norman Van Goeddel and Zhaodan Cao and Mike Rothe},
  journal={Cell},
  year={1997},
  volume={90},
  pages={373-383}
}
Abstract Activation of the transcription factor NF-κB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-κB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-κB-dependent reporter gene. A catalytically inactive mutant of CHUK is a dominant-negative inhibitor of TNF-, IL-1-, TRAF-, and NIK-induced NF-κB activation. CHUK associates with the NF-κB… Expand

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