Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E

@article{Crossley2012IdentificationAC,
  title={Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E},
  author={B. Crossley and R. Mock and S. Callison and S. Hietala},
  journal={Viruses},
  year={2012},
  volume={4},
  pages={3689 - 3700}
}
In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike… Expand
View PDF
44 Citations
Highly Influential Citations
3
Background Citations
15
Methods Citations
3

44 Citations

Citation Type

Citation Type

Evidence for an Ancestral Association of Human Coronavirus 229E with Bats
TLDR
The putative host switches leading to the formation of HCoV-229E were accompanied by major genomic changes, including deletions in the viral spike glycoprotein gene and loss of an open reading frame, and the evolutionary analyses show that animal and human viruses are genetically closely related, can exchange genetic material, and form a single viral species. Expand
Rooting the Phylogenetic Tree of Middle East Respiratory Syndrome Coronavirus by Characterization of a Conspecific Virus from an African Bat
TLDR
The full genome sequence of a CoV was determined directly from fecal material obtained from a South African Neoromicia capensis bat, providing evidence for the evolution of MERS-CoV in camels that preceded that in humans and suggesting that humans are infected by camels rather than vice versa. Expand
Metagenomic Next-Generation Sequencing Reveal Presence of a Novel Ungulate Bocaparvovirus in Alpacas
TLDR
An intestinal sample from an alpaca herd with reoccurring diarrhea and respiratory disease was submitted for next-generation sequencing, revealing the presence of a BoV strain and suggesting that AlBoV is a tentative new species. Expand
Hosts and Sources of Endemic Human Coronaviruses
TLDR
New data suggest that HCoV-229E may actually be transferred from dromedary camels similar to Middle East respiratory syndrome (MERS) coronavirus, which provides important ecological parallels to the present prepandemic pattern of host associations of the MERS coronav virus. Expand
Link of a ubiquitous human coronavirus to dromedary camels
TLDR
Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. Expand
Clinical and molecular aspects of veterinary coronaviruses
TLDR
The coronavirus infections routinely studied in veterinary medicine must be properly recognized and diagnosed not only to prevent animal disease but also to promote public health. Expand
Potential Intermediate Hosts for Coronavirus Transmission: No Evidence of Clade 2c Coronaviruses in Domestic Livestock from Ghana
The emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), nearly a decade ago with worldwide distribution, was believed to be of zoonotic origin from bats with dromedary camels as… Expand
Coronavirus Spike Protein and Tropism Changes
TLDR
Different concepts underlie these tropism changes at the cellular, tissue, and host species level, including the promiscuity or adaptability of S proteins to orthologous receptors, alterations in the proteolytic cleavage activation as well as changes in the S protein metastability. Expand
Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
TLDR
Rec recombination dynamics among three groups of coronaviruses with noteworthy impacts on human health and agriculture are analyzed, finding that all three groups undergo recombination with highly diverged viruses from sparsely sampled or undescribed lineages, which can disrupt the inference of phylogenetic relationships. Expand
Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses
TLDR
An up-to-date review of the literature currently available on animal CoVs, focusing on the molecular mechanisms that are responsible for the emergence of novel CoV strains with different antigenic, biologic and/or pathogenetic features is provided. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
Analysis of the genome sequence of an alpaca coronavirus
TLDR
Phylogenetic analysis suggests that ACoV shares the same ancestor as BCoV ENT and LUN, and most of the ORFs were highly conserved; however, the predicted spike protein has 9 and 12 amino acid differences from B coV LUN and ENT, respectively, and shows a higher relative number of changes than the other proteins. Expand
Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes
TLDR
The genome organization of the group 1b coronaviruses HCoV-NL63, PEDV and H coV-229E is identical, and the highly conserved amino acid sequence of the ORF4 protein among clinical isolates suggests that the protein plays an important role in vivo. Expand
Analysis of human coronavirus 229E spike and nucleoprotein genes demonstrates genetic drift between chronologically distinct strains.
TLDR
Phylogenetic analysis showed clustering of the isolates into four groups, with evidence of increasing divergence with time, and positive selection in the S gene was established, establishing two distinct viruses circulating during 2003 and 2004. Expand
The first complete genome sequences of clinical isolates of human coronavirus 229E
TLDR
The first full-length genome sequence of two clinical isolates from the cDNA-clone Inf-1 that is based on the lab-adapted strain VR-740 is presented, with a difference in genome organization: instead of an ORF4A and OrF4B, an intact ORF 4 was present in clinical isolate. Expand
Genome structure and transcriptional regulation of human coronavirus NL63
TLDR
The data show that HCoV-NL63 employs the discontinuous replication strategy with generation of subgenomic mRNAs during the (-) strand synthesis, which gives insight into the viral evolution and mutational patterns in coronaviral genome. Expand
Identification of a Novel Coronavirus Possibly Associated with Acute Respiratory Syndrome in Alpacas (Vicugna Pacos) in California, 2007
  • B. Crossley, B. Barr, +6 authors R. Mock
  • Biology, Medicine
  • Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2010
TLDR
The findings indicate that the ARS-associated coronavirus described is distinct from the previously reported gastrointestinal-associated coroneravirus identified in alpaca herds. Expand
PCR sequencing of the spike genes of geographically and chronologically distinct human coronaviruses 229E
TLDR
Upon translation and alignment with the published spike protein sequence of human coronavirus 229E ‘LP’ (isolated in the UK in the 1970s), it was found that variation within the translated protein sequences was rather limited. Expand
Mutational Analysis of Aminopeptidase N, a Receptor for Several Group 1 Coronaviruses, Identifies Key Determinants of Viral Host Range
TLDR
Enter and host range of these group 1 coronaviruses depend on the ability of the viral spike glycoproteins to recognize small, species-specific amino acid differences in the APN proteins of different species. Expand
Feline Coronavirus Type II Strains 79-1683 and 79-1146 Originate from a Double Recombination between Feline Coronavirus Type I and Canine Coronavirus
TLDR
The data show that the type II FCoVs have arisen from double recombination events: additional crossover sites were mapped in the ORF1ab frameshifting region of strain 79-1683 and in the 5′ half of ORF 1b of strains 79-1146. Expand
Characterization of the human coronavirus 229E (HCV 229E) gene 1.
TLDR
The sequence analysis of the HCV 229E gene 1 has revealed a high degree of similarity within the ORF 1b of HCV, MHV and IBV, whereas OrF 1a is much less conserved. Expand
...
1
2
3
4
5
...