Identification and Characterization of a Novel Thymus Aging Related Protein Rwdd1

@article{Kang2008IdentificationAC,
  title={Identification and Characterization of a Novel Thymus Aging Related Protein Rwdd1},
  author={Ning Kang and Lian Duan and Long Y. Tang and Shirong Liu and Chunman Li and Yonghai Li and Qingfeng Wilson Liu and Yu Cheng Hu and Lianxian Cui and Wei He},
  journal={Cellular and Molecular Immunology},
  year={2008},
  volume={5},
  pages={279-285}
}
By using DDRT-PCR and EST segment ligation, a novel mouse thymus involution related gene Rwdd1 was identified. The reading frame encoded a protein of 243 amino acid residues which contained an RWD domain at the N terminus. Rwdd1 expression in thymus was decreased in aged and oxidatively stressed mice. It was found to be expressed extensively in thymocytes and thymic epithelial cells. The expression level of Rwdd1 could affect the transactivation activity of androgen receptor (AR) in transiently… CONTINUE READING
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