Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*

  title={Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation*},
  author={Magnus E. Jakobsson and Anders Moen and Luc Bousset and Wolfgang Egge-Jacobsen and Stefan Kernstock and Ronald Melki and P{\aa}l {\O}. Falnes},
  journal={The Journal of Biological Chemistry},
  pages={27752 - 27763}
Background: The function of many proteins is regulated through post-translational methylation. Results: METTL21A was identified as a human protein methyltransferase targeting Hsp70 proteins, thereby altering their ability to interact with client proteins. Conclusion: METTL21A is a specific methyltransferase modulating the function of Hsp70 proteins. Significance: The activity of a human protein-modifying enzyme is unraveled, and the modification is demonstrated to have functional consequences… 

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