Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2)*

  title={Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2)*},
  author={Erna Davydova and Angela Yeuan Yen Ho and Jędrzej M. Małecki and Anders Moen and Jorrit M. Enserink and Magnus E. Jakobsson and Christoph Loenarz and P{\aa}l {\O}. Falnes},
  journal={The Journal of Biological Chemistry},
  pages={30499 - 30510}
Background: The function of many proteins is regulated through post-translational methylation. Results: The previously uncharacterized human methyltransferase FAM86A and its yeast homologue Yjr129c methylate eukaryotic translation elongation factor 2 (eEF2), altering translational frameshifting. Conclusion: Evolutionarily conserved FAM86A methyltransferase modulates the function of eEF2. Significance: The activity of a novel protein-modifying enzyme is discovered and is shown to have functional… 

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