Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2*

  title={Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2*},
  author={Vadim N. Gladyshev and Aimin Liu and Sergey V. Novoselov and Konstantin Krysan and Qi-An Sun and V. M. Kryukov and Gregory V. Kryukov and Marjorie F. Lou},
  journal={The Journal of Biological Chemistry},
  pages={30374 - 30380}
A thiol/disulfide oxidoreductase component of the GSH system, glutaredoxin (Grx), is involved in the reduction of GSH-based mixed disulfides and participates in a variety of cellular redox pathways. A single cytosolic Grx (Grx1) was previously described in mammals. We now report identification and characterization of a second mammalian Grx, designated Grx2. Grx2 exhibited 36% identity with Grx1 and had a disulfide active center containing the Cys-Ser-Tyr-Cys motif. Grx2 was encoded in the… 

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