Identification and Characterization of Sa/Scc3p Subunits in the Xenopus and Human Cohesin Complexes

@article{Losada2000IdentificationAC,
  title={Identification and Characterization of Sa/Scc3p Subunits in the Xenopus and Human Cohesin Complexes},
  author={Ana Losada and Tomoki Yokochi and Ryuji Kobayashi and Tatsuya Hirano},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={405 - 416}
}
A multisubunit protein complex, termed cohesin, plays an essential role in sister chromatid cohesion in yeast and in Xenopus laevis cell-free extracts. We report here that two distinct cohesin complexes exist in Xenopus egg extracts. A 14S complex (x-cohesin(SA1)) contains XSMC1, XSMC3, XRAD21, and a newly identified subunit, XSA1. In a second 12.5S complex (x-cohesin(SA2)), XSMC1, XSMC3, and XRAD21 associate with a different subunit, XSA2. Both XSA1 and XSA2 belong to the SA family of… CONTINUE READING
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