Identification and Characterization of 1,25-Dihydroxyvitamin D3-responsive Repressor Sequences in the Rat Parathyroid Hormone-related Peptide Gene*

@article{Kremer1996IdentificationAC,
  title={Identification and Characterization of 1,25-Dihydroxyvitamin D3-responsive Repressor Sequences in the Rat Parathyroid Hormone-related Peptide Gene*},
  author={Richard L. Kremer and Michael Sebag and C{\'e}line Champigny and Karen Meerovitch and Geoffrey N Hendy and John White and David Goltzman},
  journal={The Journal of Biological Chemistry},
  year={1996},
  volume={271},
  pages={16310 - 16316}
}
  • Richard L. Kremer, Michael Sebag, +4 authors David Goltzman
  • Published 1996
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Parathyroid hormone-related peptide (PTHRP) gene transcription is suppressed by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D3. In the present report, we examined 1,25(OH)2D3-mediated repression of PTHRP expression by transfection of PTHRP promoter/reporter constructs in normal human keratinocytes and by DNA binding. We localized an element conferring 1,25(OH)2D3-mediated repression in vivo to a 47-base pair (bp) region located −1121 to −1075 from the… CONTINUE READING

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