Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication

  title={Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication},
  author={Y. Zhang and Crystal W Burke and K. Ryman and W. Klimstra},
  journal={Journal of Virology},
  pages={11246 - 11255}
  • Y. Zhang, Crystal W Burke, +1 author W. Klimstra
  • Published 2007
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT Alpha/beta interferon (IFN-α/β) produces antiviral effects through upregulation of many interferon-stimulated genes (ISGs) whose protein products are effectors of the antiviral state. Previous data from our laboratory have shown that IFN-α/β can limit Sindbis virus (SB) replication through protein kinase R (PKR)-dependent and PKR-independent mechanisms and that one PKR-independent mechanism inhibits translation of the infecting virus genome (K. D. Ryman et al., J. Virol. 79:1487-1499… CONTINUE READING
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