Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons

  title={Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons},
  author={Xiaozhong Qian and Antonella Riccio and Yuan Sheng Zhang and David D. Ginty},

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  • L. Reichardt
  • Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2006
Three rare human genetic disorders, which result in deleterious effects on sensory perception, cognition and a variety of behaviours, have been shown to be attributable to mutations in brain-derived neurotrophic factor and two of the Trk receptors.
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Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor (*)
Results indicate that in neurons, the pathways activated by NGF and BDNF are differentially regulated and that prolonged exposure to BDNF results in the inability of TrkB to bind its ligand.
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