Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons

@article{Qian1998IdentificationAC,
  title={Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons},
  author={Xiaozhong Qian and Antonella Riccio and Yuan Sheng Zhang and David D. Ginty},
  journal={Neuron},
  year={1998},
  volume={21},
  pages={1017-1029}
}

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References

SHOWING 1-10 OF 69 REFERENCES
Neurotrophin signal transduction by the Trk receptor.
TLDR
The attempts to understand the mechanisms used by Trk to generate the many phenotypic responses of PC12 cells to NGF are summarized.
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
TLDR
Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF.
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons
TLDR
Results indicate an involvement of ras p21 in the signal transduction of neurotrophic factors in sensory, but not sympathetic or ciliary neurons, pointing to the existence of different signaling pathways not only in CNTF-responsive, but also in neurotrophin-responsive neuronal populations.
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation
TLDR
Results indicate that APS, SH2-B and Lnk form a new adaptor family that links immune receptors to signaling pathways involved in tyrosine-phosphorylation, and plays a role in linkage from BCR to Shc/Grb2 pathway.
Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor (*)
TLDR
Results indicate that in neurons, the pathways activated by NGF and BDNF are differentially regulated and that prolonged exposure to BDNF results in the inability of TrkB to bind its ligand.
Early events in neurotrophin signalling via Trk and p75 receptors
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