Identification and Characterization of Microcin S, a New Antibacterial Peptide Produced by Probiotic Escherichia coli G3/10

@article{Zschttig2012IdentificationAC,
  title={Identification and Characterization of Microcin S, a New Antibacterial Peptide Produced by Probiotic Escherichia coli G3/10},
  author={Anke Zsch{\"u}ttig and K. Zimmermann and J. Blom and A. Goesmann and Christoph Poehlmann and F. Gunzer},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
  • Anke Zschüttig, K. Zimmermann, +3 authors F. Gunzer
  • Published 2012
  • Biology, Medicine
  • PLoS ONE
  • Escherichia coli G3/10 is a component of the probiotic drug Symbioflor 2. In an in vitro assay with human intestinal epithelial cells, E. coli G3/10 is capable of suppressing adherence of enteropathogenic E. coli E2348/69. In this study, we demonstrate that a completely novel class II microcin, produced by probiotic E. coli G3/10, is responsible for this behavior. We named this antibacterial peptide microcin S (MccS). Microcin S is coded on a 50.6 kb megaplasmid of E. coli G3/10, which we have… CONTINUE READING
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