Identification and Characterization of Helicobacter pylori Genes Essential for Gastric Colonization

@article{Kavermann2003IdentificationAC,
  title={Identification and Characterization of Helicobacter pylori Genes Essential for Gastric Colonization},
  author={Holger Kavermann and Brendan Paul Burns and Katrin Angerm{\"u}ller and Stefan Odenbreit and Wolfgang Fischer and Klaus Melchers and Rainer Haas},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={813 - 822}
}
Helicobacter pylori causes one of the most common, chronic bacterial infections and is a primary cause of severe gastric disorders. To unravel the bacterial factors necessary for the process of gastric colonization and pathogenesis, signature tagged mutagenesis (STM) was adapted to H. pylori. The Mongolian gerbil (Meriones unguiculatus) was used as model system to screen a set of 960 STM mutants. This resulted in 47 H. pylori genes, assigned to 9 different functional categories, representing a… CONTINUE READING

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Helicobacter pylori, an adherent pain in the stomach

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