Identification and Characterization of GFRα-3, a Novel Co-receptor Belonging to the Glial Cell Line-derived Neurotrophic Receptor Family*

@article{Worby1998IdentificationAC,
  title={Identification and Characterization of GFR$\alpha$-3, a Novel Co-receptor Belonging to the Glial Cell Line-derived Neurotrophic Receptor Family*},
  author={Carolyn A. Worby and Quinn C. Vega and Hanna H.-J. Chao and Audrey F. Seasholtz and Robert C. Thompson and Jack E. Dixon},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={3502 - 3508}
}
A new family of neuronal survival factors comprised of glial cell line-derived neurotrophic factor (GDNF) and neurturin has recently been described (Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson, E. M., Jr., and Milbrandt, J. (1997)Nature 384, 467–470). These molecules, which are related to transforming growth factor-β, are important in embryogenesis and in the survival of distinct neuronal populations. These molecules signal through a novel receptor… 

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TLDR
It is demonstrated that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity, which supports the hypothesis that GDNF uses a multi-subunit receptor system in which GDN FR-α and Ret function as the ligand-binding and signalling components.
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TLDR
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TLDR
The cloning of a new GPI-linked receptor termed NTNR-α that is homologous with GDNFR-α and is widely expressed in the nervous system and other tissues is reported, indicating that GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI family of receptors that determines ligand specificity.
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TLDR
It is demonstrated that the glial cell line-derived neurotrophic factor (GDNF) activates RET, as measured by tyrosine phosphorylation of the intracellular catalytic domain, which indicates that RET and GDNF are components of a common signaling pathway and point to a role for GDNF in kidney development.
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TLDR
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