Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens.

@article{Kaiya2014IdentificationTD,
  title={Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens.},
  author={Hiroyuki Kaiya and Norifumi Konno and Kenji Kangawa and Minoru Uchiyama and Mikiya Miyazato},
  journal={General and comparative endocrinology},
  year={2014},
  volume={209},
  pages={106-17}
}
We identified two ghrelin receptor isoforms, the ghrelin receptor type-1a (GHS-R1a) and its alternative splice form (GHS-R1b) for West African lungfish, Protopterus annectens. Lungfish GHS-R1a and 1b comprised 361 and 281 amino acids, respectively. Lungfish GHS-R1a showed the highest identity to coelacanth GHS-R1a (80.4%). The highest expression of GHS-R1a mRNAs was seen in the brain, liver, ovary, heart, intestine, and gills. GHS-R1b mRNAs were also detected in the same tissues with GHS-R1a… CONTINUE READING