Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein.

  title={Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein.},
  author={Claudia Folli and Vito Calderone and Simone Ottonello and Angelo Bolchi and Giuseppe Zanotti and Monica Stoppini and Rodolfo Berni},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 7},
Two cellular retinol-binding proteins (CRBP I and II) with distinct tissue distributions and retinoid-binding properties have been recognized thus far in mammals. Here, we report the identification of a human retinol-binding protein resembling type I (55.6% identity) and type II (49.6% identity) CRBPs, but with a unique H residue in the retinoid-binding site and a distinctively different tissue distribution. Additionally, this binding protein (CRBP III) exhibits a remarkable sequence identity… CONTINUE READING


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