Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways.

@article{Basu2014IdentificationMO,
  title={Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways.},
  author={Dipanjan Basu and Robert Lettan and Krishnan Damodaran and Susan Strellec and Miguel Reyes-M{\'u}gica and Abdelhadi Rebbaa},
  journal={Molecular cancer therapeutics},
  year={2014},
  volume={13 6},
  pages={
          1457-67
        }
}
Embryonic signaling pathways, in particular those mediated by Wnt and TGF-β, are known to play key roles in tumor progression through the induction of epithelial-mesenchymal transition (EMT). Their simultaneous targeting could therefore represent a desirable anticancer strategy. On the basis of recent findings that both Wnt and TGF-β-associated pathways are regulated by Hippo signaling in mammalian cells, we reasoned that targeting the latter would be more effective in inhibiting EMT. In a… CONTINUE READING