Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.

@article{Li2001IdentificationLA,
  title={Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein.},
  author={Hua Li and Babett Degenhardt and Derek Tobin and Z X Yao and Kjetil Task{\'e}n and Vassilios Papadopoulos},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 12},
  pages={2211-28}
}
Peptide hormones and cAMP acutely stimulate steroid biosynthesis by accelerating the transport of cholesterol into the mitochondria. The peripheral-type benzodiazepine receptor (PBR) has been shown to be an indispensable element of the cholesterol transport machinery. Using the yeast two-hybrid system and PBR as bait, we identified a protein that interacts with PBR, the PBR-associated protein PAP7. Using the regulatory subunit RIalpha of PKA as bait, we also isolated PAP7. Glutathione-S… CONTINUE READING
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