Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.

@article{Wilding2000IdentificationEA,
  title={Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci.},
  author={Elizabeth Wilding and James Robert Brown and Alexander P. Bryant and Alison F. Chalker and David J. Holmes and Karen A. Ingraham and Serban Iordanescu and Chi Young So and Martin E. Rosenberg and Michael N. Gwynn},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 15},
  pages={
          4319-27
        }
}
The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)-pyruvate pathway are alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl diphosphate. Genomic analysis revealed that the staphylococci, streptococci, and enterococci possess genes predicted to encode all of the enzymes of the mevalonate pathway and not the GAP-pyruvate pathway, unlike Bacillus subtilis and most gram-negative bacteria studied, which possess only components of the latter pathway… CONTINUE READING
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