Identification, distribution and molecular evolution of the pacifastin gene family in Metazoa

  title={Identification, distribution and molecular evolution of the pacifastin gene family in Metazoa},
  author={Bert Breugelmans and Gert Simonet and Vincent van Hoef and Sofie Van Soest and Jozef Vanden Broeck},
  journal={BMC Evolutionary Biology},
  pages={97 - 97}
Members of the pacifastin family are serine peptidase inhibitors, most of which are produced as multi domain precursor proteins. Structural and biochemical characteristics of insect pacifastin-like peptides have been studied intensively, but only one inhibitor has been functionally characterised. Recent sequencing projects of metazoan genomes have created an unprecedented opportunity to explore the distribution, evolution and functional diversification of pacifastin genes in the animal kingdom… CONTINUE READING


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Molecular identification of SGPP-5, a novel pacifastin-like peptide precursor in the desert locust

G Simonet, I Claeys, +4 authors J VandenBroeck
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: Structural and functional characteristics of a family of serine peptidase inhibitors

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