Identification, cloning and analysis of theAspergillus niger genepacC, a wide domain regulatory gene responsive to ambient pH

@article{Maccabe1996IdentificationCA,
  title={Identification, cloning and analysis of theAspergillus niger genepacC, a wide domain regulatory gene responsive to ambient pH},
  author={Andrew P Maccabe and Johannes Petrus Theodorus Wilhelmus van den Hombergh and J. Arjan G. M. de Visser and Joan Tilburn and Herbert N. Arst},
  journal={Molecular and General Genetics MGG},
  year={1996},
  volume={250},
  pages={367-374}
}
A wide domain regulatory gene implicated in modulating gene expression in response to ambient pH has been cloned and sequenced from the industrially useful filamentous fungusAspergillus niger. This gene,pacC, is able to restore apacC + phenotype toA. nidulans pacC c 11 andpacC c 14 mutants with respect to extent of conidiation, conidial pigment intensity and acid phosphatase regulation. ThepacC gene ofA. niger comprises three exons, encodes a three-zinc-finger protein of 677 amino acids, and… CONTINUE READING