Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids

Abstract

BACKGROUND De novo production of multi-hydroxylated diterpenoids is challenging due to the lack of efficient redox systems. RESULTS In this study a new reductase/ferredoxin system from Streptomyces afghaniensis (AfR·Afx) was identified, which allowed the Escherichia coli-based production of the trihydroxylated diterpene cyclooctatin, a potent inhibitor of… (More)
DOI: 10.1186/s12934-016-0487-6

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