Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.

@article{Munday2001IdentificationCA,
  title={Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.},
  author={James R Munday and Shane Kerr and Jing Ni and Ann L. Cornish and Jiquan Zhang and Gavin Nicoll and Helen Floyd and M. G. Matt{\'e}i and Pamela L. Moore and Dan Liu and Paul R. Crocker},
  journal={The Biochemical journal},
  year={2001},
  volume={355 Pt 2},
  pages={489-97}
}
Here we characterize Siglec-10 as a new member of the Siglec family of sialic acid-binding Ig-like lectins. A full-length cDNA was isolated from a human spleen library and the corresponding gene identified. Siglec-10 is predicted to contain five extracellular Ig-like domains and a cytoplasmic tail containing three putative tyrosine-based signalling motifs. Siglec-10 exhibited a high degree of sequence similarity to CD33-related Siglecs and mapped to the same region, on chromosome 19q13.3. The… CONTINUE READING

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