Identifi cation of antifungal natural products via Saccharomyces cerevisiae bioassay : insights into macrotetrolide drug spectrum , potency and mode of action

@inproceedings{TEBBETS2013IdentifiCO,
  title={Identifi cation of antifungal natural products via Saccharomyces cerevisiae bioassay : insights into macrotetrolide drug spectrum , potency and mode of action},
  author={BRAD TEBBETS and YU ZHIGUO and DOUGLAS STEWART and ̂ LI-XINGZHAO and ̂ YIJIANG and ̂ LI-HUAXU and David K. Andes and BEN SHEN and BRUCE KLEIN},
  year={2013}
}
  • BRAD TEBBETS, YU ZHIGUO, +6 authors BRUCE KLEIN
  • Published 2013
individuals with compromised immune systems, the complexity of medical procedures that render patients vulnerable, and the advancing age of our population [1]. Current antifungal drugs are insuffi cient due to the limited selection of medications, their adverse side-effects, and the emergence of resistance to them by fungal pathogens. A recent study reported that 17% of clinical isolates of Candida albicans had increased resistance to fl uconazole, a current frontline drug [2]. Therefore, novel… CONTINUE READING