Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.

Abstract

The ability of antibodies raised against disordered short peptides to interact frequently with their cognate sequences in intact folded proteins has raised a major theoretical issue in protein chemistry. We propose to address this issue by using antibodies raised against peptides with identical sequences, but different conformations, in pairs of unrelated… (More)

Cite this paper

@article{Wilson1985IdenticalSP, title={Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.}, author={Ingred Wilson and Daniel H. Haft and Elizabeth D. Getzoff and J. A. Tainer and Richard Allen Lerner and S. Brenner}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1985}, volume={82 16}, pages={5255-9} }