• Corpus ID: 29806656

Identical antagonist selectivity of central and peripheral alpha 1-adrenoceptors.

@article{Timmermans1981IdenticalAS,
  title={Identical antagonist selectivity of central and peripheral alpha 1-adrenoceptors.},
  author={Pieter B.M.W.M. Timmermans and F. Karamat Ali and H. Y. Kwa and Andreas Schoop and F P Slothorst-Grisdijk and Pieter A. van Zwieten},
  journal={Molecular pharmacology},
  year={1981},
  volume={20 2},
  pages={
          295-301
        }
}
The present study was undertaken to test the relationship between binding affinity for alpha 1 -adrenoceptors and functional antagonism of drug-induced effects mediated by this type of alpha 1 -receptor sites for alpha -sympatholytic drugs. The radioligand [ 3 H]prazosin was used to identify alpha 1 -adrenoceptors in rat brain membranes. The specific binding of [ 3 H]prazosin was rapid, reversible, saturable, and of high affinity ( K D = 0.21 nM) and involved a single class of binding sites ( B… 
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