Identical TP53 mutations in pelvic carcinosarcomas and associated serous tubal intraepithelial carcinomas provide evidence of their clonal relationship

@article{Ardighieri2016IdenticalTM,
  title={Identical TP53 mutations in pelvic carcinosarcomas and associated serous tubal intraepithelial carcinomas provide evidence of their clonal relationship},
  author={Laura Ardighieri and Luigi Mori and Sara Conzadori and Mattia Bugatti and Marcella Falchetti and Carla Maria Donzelli and Antonella Ravaggi and Franco Edoardo Odicino and Fabio F. Facchetti},
  journal={Virchows Archiv},
  year={2016},
  volume={469},
  pages={61-69}
}
Pelvic carcinosarcomas (PCSs) are rare aggressive biphasic tumors that localize in the ovary, fallopian tube, or peritoneum and present frequently as bilateral disease. We undertook a morphological, p53 immunohistochemical and TP53 gene mutational analysis study in a single institution cohort of 16 PCSs in order to investigate the nature of bilateral tumors and to shed light on their origin and pathogenesis. Of the 16 patients, 10 presented with bilateral disease, 6 with a carcinosarcoma in… CONTINUE READING

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