Identi fi cation of a soluble guanylate cyclase in RBCs : preserved activity in patients with coronary artery disease

  • Miriam M. Cortese-Krotta, Evanthia Mergiac, +11 authors Malte Kelma
  • Published 2017


Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in platelets. Red blood cells (RBCs) are known to produce NO under hypoxic and normoxic conditions; however evidence of expression and/or activity of sGC and downstream signaling pathway… (More)

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