• DOI:10.1212/01.WNL.0000068549.52812.0F
Corpus ID: 36556782

Idebenone treatment in Friedreich’s ataxia

@article{Buyse2003IdebenoneTI,
  title={Idebenone treatment in Friedreich’s ataxia},
  author={G. Buyse and L. Mertens and G. di Salvo and I. Matthijs and F. Weidemann and B. Eyskens and W. Goossens and N. Goemans and G. Sutherland and J. V. Van Hove},
  journal={Neurology},
  year={2003},
  volume={60},
  pages={1679 - 1681}
}

G. Buyse, L. Mertens, +7 authors J. V. Van Hove

Published 2003

Medicine

Neurology

The authors report 1-year prospective data on eight patients with Friedreich ataxia. Idebenone did not halt the progression of ataxia. At the end of therapy, cardiac ultrasound demonstrated significant reduction of cardiac hypertrophy in six of eight patients. Cardiac strain and strain rate imaging showed that the reduction of hypertrophy is preceded by an early and linear improvement in cardiac function. Idebenone reduced erythrocyte protoporphyrin IX levels in five of six patients with… CONTINUE READING

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