Idebenone in Friedreich's ataxia

@article{Tonon2008IdebenoneIF,
  title={Idebenone in Friedreich's ataxia},
  author={C. Tonon and R. Lodi},
  journal={Expert Opinion on Pharmacotherapy},
  year={2008},
  volume={9},
  pages={2327 - 2337}
}
  • C. Tonon, R. Lodi
  • Published 2008
  • Medicine
  • Expert Opinion on Pharmacotherapy
  • Background: Friedreich's ataxia is an autosomal recessive neurodegenerative disease where impaired mitochondrial function and excessive production of free radicals play a central pathogenetic role. Idebenone, a synthetic analogue of coenzyme Q, is a powerful antioxidant that was first administrated to Friedreich's ataxia patients less than 10 years ago. Objective: The aim of this study was to evaluate the efficacy of idebenone administration and define the optimal dosage. Methods: A critical… CONTINUE READING
    11 Citations
    Intermediate-dose idebenone and quality of life in Friedreich ataxia.
    • 17
    Iron–sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia
    • 104
    Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies.
    • 44
    A Strategy for Suppressing Redox Stress within Mitochondria.
    • 22
    Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.
    • 296
    Current concepts and controversies in neurodegeneration with brain iron accumulation.
    • 18

    References

    SHOWING 1-10 OF 114 REFERENCES
    Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia
    • 224
    • Highly Influential
    • PDF
    Heart Hypertrophy and Function Are Improved by Idebenone in Friedreich's Ataxia
    • 85
    Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial
    • 252
    • Highly Influential
    • PDF
    Friedreich's ataxia: idebenone treatment in early stage patients.
    • 102
    • Highly Influential
    Idebenone in patients with Friedreich ataxia
    • 78
    Idebenone treatment in paediatric and adult patients with Friedreich ataxia: long-term follow-up.
    • M. Pineda, J. Arpa, +12 authors R. Artuch
    • Medicine
    • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
    • 2008
    • 91
    • Highly Influential
    Friedreich's ataxia.
    • 150
    Antioxidant enzymes in blood of patients with Friedreich's ataxia
    • 61
    • PDF
    Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up.
    • 196
    • PDF