Idebenone in Friedreich's ataxia

  title={Idebenone in Friedreich's ataxia},
  author={C. Tonon and R. Lodi},
  journal={Expert Opinion on Pharmacotherapy},
  pages={2327 - 2337}
  • C. Tonon, R. Lodi
  • Published 2008
  • Medicine
  • Expert Opinion on Pharmacotherapy
  • Background: Friedreich's ataxia is an autosomal recessive neurodegenerative disease where impaired mitochondrial function and excessive production of free radicals play a central pathogenetic role. Idebenone, a synthetic analogue of coenzyme Q, is a powerful antioxidant that was first administrated to Friedreich's ataxia patients less than 10 years ago. Objective: The aim of this study was to evaluate the efficacy of idebenone administration and define the optimal dosage. Methods: A critical… CONTINUE READING
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