Idebenone in Friedreich's ataxia.

  title={Idebenone in Friedreich's ataxia.},
  author={Caterina Tonon and Raffaele Lodi},
  journal={Expert opinion on pharmacotherapy},
  volume={9 13},
BACKGROUND Friedreich's ataxia is an autosomal recessive neurodegenerative disease where impaired mitochondrial function and excessive production of free radicals play a central pathogenetic role. Idebenone, a synthetic analogue of coenzyme Q, is a powerful antioxidant that was first administrated to Friedreich's ataxia patients less than 10 years ago. OBJECTIVE The aim of this study was to evaluate the efficacy of idebenone administration and define the optimal dosage. METHODS A critical… CONTINUE READING