IdeS, a highly specific immunoglobulin G (IgG)-cleaving enzyme from Streptococcus pyogenes, is inhibited by specific IgG antibodies generated during infection.

@article{kesson2006IdeSAH,
  title={IdeS, a highly specific immunoglobulin G (IgG)-cleaving enzyme from Streptococcus pyogenes, is inhibited by specific IgG antibodies generated during infection.},
  author={Per {\AA}kesson and Linnea Moritz and Mikael Truedsson and Bertil Christensson and Ulrich von Pawel-Rammingen},
  journal={Infection and immunity},
  year={2006},
  volume={74 1},
  pages={497-503}
}
IdeS, a recently discovered cysteine proteinase secreted by the important human pathogen Streptococcus pyogenes, interferes with phagocytic killing by specifically cleaving the heavy chain of immunoglobulin G. The fact that the enzyme targets one of the key molecules of the adapted immune response raised the question of whether an antibody response against IdeS could inhibit, i.e., neutralize, enzyme activity. Paired acute- and convalescent-phase serum samples from patients with… CONTINUE READING

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