Idarucizumab for Dabigatran Reversal - Full Cohort Analysis.

  title={Idarucizumab for Dabigatran Reversal - Full Cohort Analysis.},
  author={Charles V. Pollack and Paul A. Reilly and Joanne van Ryn and John W. Eikelboom and Stephan Glund and Richard Alan Bernstein and Robert Dubiel and Menno V. Huisman and Elaine M. Hylek and Chak-wah Kam and Pieter Willem Kamphuisen and Joerg Kreuzer and Jerrold H Levy and G. Royle and Frank W Sellke and Joachim Stangier and Thorsten Steiner and Peter Verhamme and Bushi Wang and Laura Young and Jeffrey I Weitz},
  journal={The New England journal of medicine},
  volume={377 5},
BACKGROUND Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran. METHODS We performed a multicenter, prospective, open-label study to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant effect of dabigatran in patients who had uncontrolled bleeding (group A) or were about to undergo an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant… CONTINUE READING
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Effect of age and renal function on idarucizumab pharmacokinetics and idarucizumab-mediated reversal of dabigatran anticoagulant activity in a randomized, double-blind, crossover phase Ib study

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