Idarucizumab Improves Outcome in Murine Brain Hemorrhage Related to Dabigatran.

  title={Idarucizumab Improves Outcome in Murine Brain Hemorrhage Related to Dabigatran.},
  author={S Na and Eva Mracsk{\'o} and Joanne van Ryn and Roland Veltkamp},
  journal={Annals of neurology},
  volume={78 1},
Lack of specific antidotes is a major concern in intracerebral hemorrhage (ICH) related to direct anticoagulants including dabigatran (OAC-ICH). We examined the efficacy of idarucizumab, an antibody fragment binding to dabigatran, in a mouse model of OAC-ICH. Dabigatran etexilate (DE) dose-dependently prolonged diluted thrombin time and tail-vein bleeding time, which were reversed by idarucizumab. Pretreatment with DE increased intracerebral hematoma volume and cerebral hemoglobin content… CONTINUE READING
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