Idarubicin, an Anthracycline, Induces Oxidative DNA Damage in the Presence of Copper (II)

@article{Mizutani2020IdarubicinAA,
  title={Idarubicin, an Anthracycline, Induces Oxidative DNA Damage in the Presence of Copper (II)},
  author={Hideki Mizutani and Chiaki Shiga and Masanori Imai and Kenji Ikemura and Yuki Kitamura and Kin-ya Ohta and Daisuke Miyazawa and Mayuko Sakanashi and Tomoko Tahira and Tohru Maeda and Yusuke Hiraku and Shosuke Kawanishi},
  journal={AntiCancer Research},
  year={2020},
  volume={40},
  pages={5399 - 5404}
}
Background/Aim: The aim of the present study was to investigate whether idarubicin (IDR) induces oxidative DNA damage in the presence of copper (II). Materials and Methods: DNA damage was evaluated by pBR322 plasmid DNA cleavage. The formation of oxidative stress markers [O2•− and 8-hydroxy-2’-deoxyguanosine (8-OHdG)] was analysed. Results: IDR induced DNA damage and O2•− and 8-OHdG generation in the presence of copper (II). Conclusion: IDR induced oxidative DNA damage in the presence of copper… Expand

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