Id4 promotes cisplatin resistance in lung cancer through the p38 MAPK pathway.

@article{Qi2016Id4PC,
  title={Id4 promotes cisplatin resistance in lung cancer through the p38 MAPK pathway.},
  author={Kang Qi and Yang Li and Xuebing Li and Xing Lei and Bo Wang and Lianbin Zhang and Xiangyang Chu},
  journal={Anti-cancer drugs},
  year={2016},
  volume={27 10},
  pages={
          970-8
        }
}

• Kang Qi, Yang Li, +4 authors Xiangyang Chu
• Published 2016 in Anti-cancer drugs
• DOI:10.1097/CAD.0000000000000414

Inhibitor of differentiation 4 (Id4) plays an important role in tumorigenesis, but its role in cancer chemoresistance remains unclear. Our study showed that Id4 expression in cisplatin-resistant A549/DDP cells was higher than that in parental A549 cells. Moreover, overexpression of Id4 in A549 cells results in cisplatin resistance and apoptosis inhibition, while increasing the IC50 for cisplatin through activation of phospho-p38 MAPK. However, Id4 knockdown in A549/DDP cells was shown to… CONTINUE READING

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