Id4 promotes cisplatin resistance in lung cancer through the p38 MAPK pathway.

@article{Qi2016Id4PC,
  title={Id4 promotes cisplatin resistance in lung cancer through the p38 MAPK pathway.},
  author={Kang Qi and Yang Li and Xuebing Li and Xing Lei and Bo Wang and Lianbin Zhang and Xiangyang Chu},
  journal={Anti-cancer drugs},
  year={2016},
  volume={27 10},
  pages={
          970-8
        }
}
Inhibitor of differentiation 4 (Id4) plays an important role in tumorigenesis, but its role in cancer chemoresistance remains unclear. Our study showed that Id4 expression in cisplatin-resistant A549/DDP cells was higher than that in parental A549 cells. Moreover, overexpression of Id4 in A549 cells results in cisplatin resistance and apoptosis inhibition, while increasing the IC50 for cisplatin through activation of phospho-p38 MAPK. However, Id4 knockdown in A549/DDP cells was shown to… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 50 references

( NSCLC ) patients treated with first - line platinumbased chemotherapy across Europe : FRAME prospective observational study

S Dasari, PB Tchounwou
Lung Cancer • 2015

Cancer statistics , 2015

KD Miller
CA Cancer J Clin • 2015